OUR PRODUCTS
FORMULATION
Each 5 mL of  reconstituted contains Cefuroxime Axetil USP eq. to anhydrous Cefuroxime, 250mg; Clavulanate  Potassium USP eq. to Clavulanic Acid 62.5mg 125 mg.
INDICATION

For treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsilitis, pharyngitis, ear infections, skin infections, gonorrhea, and urinary tract infections.

DOSAGE AND ADMINISTRATION
Uncomplicated Urinary tract Infection:Child 10 mg/kg 2x a day
Respiratory tract Infections: Child > 3months :125 mg 2x a day or 10 mg/kg 2x a day.
Max Dose:250 mg daily
Otitis Media:Child>2 years 250mg 2x a day or 15 mg/kg 2x a day up to 500mg daily
Meningitis: Child:200-240 mg/kg/day in -4 divided doses,decreased to 100 mg/kg/day after 3 days or once symptoms have improved.
Neonate:100mg/kg/day,decreased to 50 mg/kg/day when control has been achieved.

OVERDOSAGE

Reports indicate that the ingestion of large amounts of Clarithromycin can be expected to produce gastro-instestinal symptoms. Adverse reactions accompanying overdosage should be treated by gastric lavage and general supportive measures. One patient who had a history of bipolar disorders ingested 8 grams of Clarithromycin and showed altered mental status, paranoid behavior, hypokalaemia. As with other macrolides, Clarithromycin serum levels are not expected to be appropriately affected by hemodialysis or peritoneal dialysis.

CONTRAINDICATION

Clarithromycin is contraindicated in patients with known hypersensitivity to clarithromycin, erythromycin or any of the macrolide antibiotics. Clarithromycin is contraindicated in patients receiving terfenadine therapy who have pre-existing cardiac abnormalities (arrhythmia, bradycardia, QT interval prolongation, ischemic heart disease, congestive heart failure) or electrolyte disturbances.

PRECAUTIONS

Caution is required in patients with impaired renal or hepatic function. It should not be used during pregnancy if possible: high doses have been associated with embryotoxicity in animal studies.

ADVERSE EFFECTS

Ciprofloxacin is generally well-tolerated. The commonly reported side effects are diarrhea, vomiting, abdominal pain, headache, restlessness and rash. Other side effects reported very rarely are arthralgia, and increase in serum transaminase level.

DRUG INTERACTIONS

Ciprofloxacin absorption when co-administered with magnesium-aluminum antacids. Other cations, such as calcium and probably zinc appear to interact in similar manner. Theophylline serum concentration have been found to be markedly elevated when co-administered with Ciprofloxacin. At doses used for systematic infections, Ciprofloxacin decreases theopylline clearance by approximately 30%. A decreased Ciprofloxacin absorption.

GERMANY
KOHLENHFSTR
67663 KAISERSLAUTERN
GERMANY

ASIA PACIFIC – PHILIPPINES
18 Malumanay St.,

Brgy. Sikatuna Village
Diliman Quezon City

EMAIL
msd@ivppharma.com

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